Interim analysis of robot-assisted radical hysterectomy in Japan: a multicenter, prospective interventional single-arm clinical trial

  • 24-11-17 00:00AM
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sThis study evaluates robot-assisted radical hysterectomy (RARH) using the Da Vinci surgical system in a multicenter, prospective clinical trial involving 101 patients with cervical cancer. Compared to historical open radical hysterectomy (RH) data, RARH demonstrated reduced blood loss (average 138 mL), shorter hospital stays, and comparable oncological outcomes. The primary endpoint, defined as successful surgery with blood loss ≤300 mL and negative margins, was achieved in 89% of cases, exceeding the threshold of 75%. Oncological outcomes showed a recurrence-free survival (RFS) rate of 82.7% and an overall survival (OS) rate of 96.9% over 37 months. Despite longer operative times due to the learning curve, RARH proved safe, with low complication rates and significant preservation of urinary function and quality of life. These findings support RARH as a feasible and less invasive alternative to conventional RH for early-stage cervical cancer.

 

Citation

Ito H, Yokoyama Y, Kyo S, Mandai M, Kosaka K, Kobayashi H, Miyagi E, Onuki M, Matsumoto K, Matsumura N, Umemura K, Ishikawa H, Isaka K. Interim analysis of robot-assisted radical hysterectomy in Japan: a multicenter, prospective interventional single-arm clinical trial. BMC Cancer. 2024 Nov 7;24(1):1360. 

 

Link

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-024-13090-z 

 


 

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